Abstract
The present study investigated the influence of BM-78, BM-121 (gamma-aminobutyric acid amide derivatives) and BM-42, BM-43 (phthalimide precursors of BM-78 and BM-121) on the spontaneous locomotor activity and on the picrotoxin-induced seizures. Results of pharmacological in vivo examination of the effects of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors (compounds BM-78, BM-121, BM-42, BM-43), presented in this paper showed that all the compounds had different but clear influence on CNS in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / pharmacology*
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Brain / drug effects*
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GABA Antagonists
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Male
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Mice
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Motor Activity / drug effects
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Phthalimides / chemistry
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Phthalimides / pharmacology*
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Picrotoxin
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Seizures / chemically induced
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Seizures / prevention & control
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gamma-Aminobutyric Acid / analogs & derivatives*
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gamma-Aminobutyric Acid / chemistry
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gamma-Aminobutyric Acid / pharmacology*
Substances
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Anticonvulsants
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GABA Antagonists
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Phthalimides
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Picrotoxin
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gamma-Aminobutyric Acid