Evaluation of mandibular mass lesions is a perplexing clinical problem. Some of these lesions have very similar clinical presentation and even similar or overlapping imaging features. Plain radiographs and orthopantomograms are frequently requisitioned for the diagnosis and are helpful in localization and characterization of these lesions. However, the specificity of diagnosis remains low. A study was undertaken to further characterize these lesions using Computed Tomography (CT) and analysis of cross sectional images of various mandibular mass lesions. Of these, imaging features of ameloblastoma and central giant cell granuloma (CGCG) were studied and compared, which is reported in this paper.