Abstract
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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DNA Repair / genetics
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DNA Repair / physiology*
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DNA, Fungal / physiology
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DNA-Binding Proteins*
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Deoxyribonucleases / physiology*
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Endodeoxyribonucleases / physiology*
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Exodeoxyribonucleases / physiology*
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Fungal Proteins / physiology*
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Genes, cdc / physiology
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Humans
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Macromolecular Substances
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Nuclear Proteins / physiology
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Phosphorylation
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Saccharomyces cerevisiae / physiology
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Saccharomyces cerevisiae Proteins*
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Signal Transduction / physiology
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Telomere / physiology
Substances
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DNA, Fungal
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DNA-Binding Proteins
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Fungal Proteins
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Macromolecular Substances
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Nuclear Proteins
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RAD50 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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XRS2 protein, S cerevisiae
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Deoxyribonucleases
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Endodeoxyribonucleases
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Exodeoxyribonucleases
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MRE11 protein, S cerevisiae