Transient activation of a somatosensory area in painful hallucinations shown by fMRI

Neuroreport. 2002 May 7;13(6):805-8. doi: 10.1097/00001756-200205070-00014.

Abstract

The disturbance of somatosensory perception and bodily experiences, including somatosensory hallucinations, are main features of the coenaesthesia sub-syndrome of schizophrenia. We used functional MRI to study a coenaesthesia patient with rapidly fluctuating painful somatosensory hallucinatory perceptions. Transient brain activations accompanying hallucinations were similar to the pattern elicited in a control experiment (non-painful tactile stimulation). However, an area in the medial parietal cortex, including parts of the precuneus and previously characterised as a supplementary sensory area, was activated significantly stronger during hallucinations than the control condition. This finding demonstrates elevated brain activity in a somatosensory area accompanying painful somatic hallucinations.

MeSH terms

  • Brain Mapping
  • Female
  • Functional Laterality / physiology
  • Hallucinations / etiology
  • Hallucinations / pathology
  • Hallucinations / physiopathology*
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Pain / etiology
  • Pain / pathology
  • Pain / physiopathology*
  • Parietal Lobe / pathology
  • Parietal Lobe / physiopathology*
  • Physical Stimulation
  • Schizophrenia / complications
  • Schizophrenia / pathology
  • Schizophrenia / physiopathology*
  • Temporal Lobe / pathology
  • Temporal Lobe / physiopathology
  • Time Factors
  • Touch / physiology