Abstract
A series of indol-2 and 3-carboxamides were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). Substitution on indol nitrogen with benzyl and p-fluorobenzyl group of indole-2 carboxamides 8, 10, 11 provides fairly active COX-2 enzyme inhibitors.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amides / chemical synthesis*
-
Amides / chemistry
-
Amides / pharmacology*
-
Chemical Phenomena
-
Chemistry, Physical
-
Cyclooxygenase 1
-
Cyclooxygenase 2
-
Cyclooxygenase 2 Inhibitors
-
Cyclooxygenase Inhibitors / chemical synthesis*
-
Cyclooxygenase Inhibitors / chemistry
-
Cyclooxygenase Inhibitors / pharmacology*
-
Drug Design
-
Humans
-
In Vitro Techniques
-
Indicators and Reagents
-
Indoles / chemical synthesis*
-
Indoles / chemistry
-
Indoles / pharmacology*
-
Isoenzymes / drug effects
-
Magnetic Resonance Spectroscopy
-
Membrane Proteins
-
Prostaglandin-Endoperoxide Synthases / drug effects
Substances
-
Amides
-
Cyclooxygenase 2 Inhibitors
-
Cyclooxygenase Inhibitors
-
Indicators and Reagents
-
Indoles
-
Isoenzymes
-
Membrane Proteins
-
Cyclooxygenase 1
-
Cyclooxygenase 2
-
PTGS1 protein, human
-
PTGS2 protein, human
-
Prostaglandin-Endoperoxide Synthases