Clozapine and full-dose concomitant chemoradiation therapy in a schizophrenic patient with nasopharyngeal cancer

Tumori. 2002 Jan-Feb;88(1):59-60.

Abstract

Clozapine is a neuroleptic drug used in selected schizophrenic patients. Its use is limited because of unpredictable myelotoxicity. The potentially dangerous interaction between cancer treatment and clozapine is virtually unknown. A 37-year-old schizophrenic patient under treatment with clozapine, diagnosed with undifferentiated nasopharyngeal carcinoma, was treated with full-dose cisplatin and concomitant radiotherapy without reporting significant neutropenia. Clozapine may be cautiously administered when full-dose concomitant chemoradiation therapy is required.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use*
  • Antipsychotic Agents / therapeutic use*
  • Cisplatin / therapeutic use*
  • Clozapine / therapeutic use*
  • Combined Modality Therapy
  • Dose Fractionation, Radiation
  • Humans
  • Male
  • Nasopharyngeal Neoplasms / complications
  • Nasopharyngeal Neoplasms / drug therapy*
  • Nasopharyngeal Neoplasms / radiotherapy*
  • Neutropenia / chemically induced
  • Radiotherapy Dosage
  • Schizophrenia / complications
  • Schizophrenia / drug therapy*

Substances

  • Antineoplastic Agents
  • Antipsychotic Agents
  • Clozapine
  • Cisplatin