Major role for the carboxylic function of cetirizine and levocetirizine in their binding characteristics to human H1-histamine-receptors

Inflamm Res. 2002 Apr:51 Suppl 1:S79-80. doi: 10.1007/pl00022458.
No abstract available

MeSH terms

  • Animals
  • CHO Cells
  • Carboxylic Acids / chemistry
  • Carboxylic Acids / metabolism*
  • Cell Membrane / metabolism
  • Cells, Cultured
  • Cetirizine / chemistry*
  • Cetirizine / metabolism*
  • Cloning, Molecular
  • Cricetinae
  • Histamine H1 Antagonists / chemistry*
  • Histamine H1 Antagonists / metabolism*
  • Humans
  • Kinetics
  • Lysine / chemistry
  • Lysine / metabolism
  • Mutagenesis, Site-Directed
  • Stereoisomerism

Substances

  • Carboxylic Acids
  • Histamine H1 Antagonists
  • Lysine
  • Cetirizine