GTPase signaling: bridging the GAP between ARF and Rho

Lorraine C Santy; James E Casanova

doi:10.1016/s0960-9822(02)00860-6

GTPase signaling: bridging the GAP between ARF and Rho

Curr Biol. 2002 May 14;12(10):R360-2. doi: 10.1016/s0960-9822(02)00860-6.

Authors

Lorraine C Santy¹, James E Casanova

Affiliation

¹ Department of Cell Biology, University of Virginia, Health Sciences Center, P.O. Box 800732, Charlottesville, Virginia 22908-0732, USA.

PMID: 12015138
DOI: 10.1016/s0960-9822(02)00860-6

Abstract

Membrane traffic and actin cytoskeleton dynamics are intimately linked, and GTPases of the Rho and ARF families may work together to regulate both. Recent studies have identified a family of GTPase activating proteins (GAPs) that contain both ARF-GAP and Rho-GAP domains, providing the first direct link between these two signaling pathways.

MeSH terms

ADP-Ribosylation Factors / metabolism*
Adaptor Proteins, Signal Transducing*
Animals
Carrier Proteins / chemistry
Carrier Proteins / metabolism
GTPase-Activating Proteins / chemistry
GTPase-Activating Proteins / metabolism*
Humans
Signal Transduction*
rho GTP-Binding Proteins / metabolism*

Substances

ARAP1 protein, human
ARAP3 protein, human
Adaptor Proteins, Signal Transducing
Carrier Proteins
GTPase-Activating Proteins
ADP-Ribosylation Factors
rho GTP-Binding Proteins