Specificity of gene regulation

Cell. 2002 May 3;109(3):267-70. doi: 10.1016/s0092-8674(02)00740-7.

Abstract

The physiologically coordinated expression of our genome requires exquisite regulation of gene specificity. Recent advances demonstrate that this formidable task is accomplished by diverse mechanisms and networks that operate at distinct levels within the nucleus.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / physiology
  • Chromatin / metabolism
  • Gene Expression Regulation / physiology*
  • Humans
  • Models, Genetic
  • Nuclear Proteins / metabolism
  • Nucleosomes / metabolism
  • Peptide Initiation Factors / metabolism
  • Promoter Regions, Genetic
  • Protein Conformation
  • RNA Polymerase II / metabolism
  • Transcription Factors / metabolism
  • Transcription, Genetic / physiology

Substances

  • Chromatin
  • Nuclear Proteins
  • Nucleosomes
  • Peptide Initiation Factors
  • Transcription Factors
  • RNA Polymerase II