Abstract
Bis-lentivirus lytic protein 1 (Bis-LLP1) and polymyxin B exhibited similar killing activities against Serratia marcescens. By electron microscopy, bis-LLP1 interacted with the outer and cytoplasmic bacterial membranes, while polymyxin B affected only the outer membrane. The results of standard biochemical probes supported the findings of the electron microscopy studies, suggesting that these antimicrobial peptides have different mechanisms of action.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Cell Membrane / drug effects
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Cell Membrane / ultrastructure
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Cytoplasm / drug effects
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Cytoplasm / ultrastructure
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Freeze Fracturing
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Membrane Proteins / pharmacology*
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Microbial Sensitivity Tests
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Microscopy, Electron
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Polymyxin B / pharmacology
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Serratia marcescens / drug effects*
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Serratia marcescens / ultrastructure
Substances
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Anti-Bacterial Agents
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Membrane Proteins
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Polymyxin B