Comparative study of permanganate oxidation reactions of nucleotide bases by spectroscopy

Bioorg Chem. 2002 Apr;30(2):133-7. doi: 10.1006/bioo.2002.1238.

Abstract

The permanganate oxidation of free nucleotide bases was successfully studied in aqueous solution of tetraethylammonium chloride using spectroscopic techniques. The reaction was highly selective toward thymine and uracil, less with cytosine, very little reaction on guanine, and no reaction on adenine.

Publication types

  • Comparative Study

MeSH terms

  • Adenine / chemistry
  • Adenine / metabolism
  • Cytosine / chemistry
  • Cytosine / metabolism
  • Guanine / chemistry
  • Guanine / metabolism
  • Kinetics
  • Manganese Compounds / chemistry
  • Manganese Compounds / metabolism*
  • Methods
  • Oxidation-Reduction / drug effects
  • Oxides / chemistry
  • Oxides / metabolism*
  • Potassium Permanganate / chemistry
  • Potassium Permanganate / metabolism
  • Purines / chemistry
  • Purines / metabolism*
  • Pyrimidines / chemistry
  • Pyrimidines / metabolism*
  • Spectrum Analysis
  • Thymine / chemistry
  • Thymine / metabolism
  • Uracil / chemistry
  • Uracil / metabolism

Substances

  • Manganese Compounds
  • Oxides
  • Purines
  • Pyrimidines
  • Potassium Permanganate
  • permanganic acid
  • Uracil
  • Guanine
  • Cytosine
  • Adenine
  • Thymine