Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B

V Rajendran; Ashima Saxena; Bhupendra P Doctor; Alan P Kozikowski

doi:10.1016/s0960-894x(02)00204-4

Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B

Bioorg Med Chem Lett. 2002 Jun 3;12(11):1521-3. doi: 10.1016/s0960-894x(02)00204-4.

Authors

V Rajendran¹, Ashima Saxena, Bhupendra P Doctor, Alan P Kozikowski

Affiliation

¹ Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington DC 20007-2197, USA.

PMID: 12031333
DOI: 10.1016/s0960-894x(02)00204-4

Abstract

The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.

Publication types

Comparative Study
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alkaloids / chemical synthesis*
Alkaloids / chemistry
Alkaloids / pharmacology*
Cholinesterase Inhibitors / chemical synthesis*
Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / pharmacology*
Kinetics
Organothiophosphorus Compounds / chemistry
Structure-Activity Relationship

Substances

Alkaloids
Cholinesterase Inhibitors
Organothiophosphorus Compounds
huperzine B
2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide