Diterpenoids from the stem bark of Croton zambesicus

Phytochemistry. 2002 Jun;60(4):345-9. doi: 10.1016/s0031-9422(02)00034-1.

Abstract

Three clerodane diterpenoids, crotozambefurans A, B and C were isolated from the stem bark of Croton zambesicus together with the known clerodane crotocorylifuran and two trachylobanes: 7 beta-acetoxytrachyloban-18-oic acid and trachyloban-7 beta, 18-diol. Betulinol, lupeol, sitosterol and its 3 beta-glucopyranosyl derivative were also obtained. The structures of crotozambefurans A, B and C were determined, respectively, as: 15,16-epoxy-1,3,13(16),14-clerodatetraen-20,12-olide-18,19-dioic acid dimethylester, 15,16-epoxy-1,3,13(16),14-clerodatetraen-18,19,20-trioic acid trimethylester and 15,16-epoxy-3,13(16),14-clerodatrien-19,1 alpha:20,12-diolide-18-oic acid methylester, using spectroscopic analysis, especially, NMR spectra in conjunction with 2D experiments, COSY, HSQC, HMBC and TOCSY.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cameroon
  • Chromatography / methods
  • Croton / chemistry*
  • Diterpenes / chemistry*
  • Furans / chemistry
  • Mass Spectrometry / methods
  • Nuclear Magnetic Resonance, Biomolecular / methods
  • Plant Bark / chemistry*
  • Plant Extracts / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Stereoisomerism

Substances

  • Diterpenes
  • Furans
  • Plant Extracts