Abstract
Free radicals have been hypothesized to play a key role in the evolution of periventricular leukomalacia, although direct evidence of oxidative injury in the human infant is lacking. This case report is the first to demonstrate a marked elevation in the levels of lipid and protein oxidative products in the cerebrospinal fluid during the evolution of periventricular leukomalacia in a premature infant with meningitis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers
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Female
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Humans
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Infant, Newborn
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Infant, Premature*
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Leukomalacia, Periventricular / cerebrospinal fluid*
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Leukomalacia, Periventricular / microbiology
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Leukomalacia, Periventricular / pathology
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Lipid Peroxidation*
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Magnetic Resonance Imaging
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Meningitis, Bacterial / cerebrospinal fluid*
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Meningitis, Bacterial / complications
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Oxidative Stress*