The Authors report a case of appendicular mucocele admitted in an emergency setting in the Emergency Department (DEA II). The patient, 78 y-old man, went to attention complaining diffuse abdominal pain: physical examination revealed mild tenderness and right lower quadrant pain to palpation. Rx plain and CT scan demonstrated a right iliac fossa cystic lesion with mural calcification, adherent to the caecum. On basis of imaging, clinical and laboratory findings the patient underwent surgery postoperative diagnosis was mucocele of the appendix. The aim of this report is to discuss the role of imaging and clinical approach in treatment of appendicular mucocele, which is known to be so aspecific in presentation, especially when it occurs in an emergency setting.