Abstract
The thrombotic microangiopathies (TMA) are a group of diseases associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction. These seemingly disparate entities share in common a pathogenic mechanism involving endothelial injury and thrombus formation. Prognosis and treatment depend on the nature of the underlying disease.
MeSH terms
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Anemia, Hemolytic* / complications
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Anemia, Hemolytic* / etiology
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Anemia, Hemolytic* / physiopathology
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Endothelium, Vascular / pathology
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Hemolytic-Uremic Syndrome / etiology
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Humans
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Kidney Diseases / pathology
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Microcirculation
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Purpura, Thrombotic Thrombocytopenic / etiology
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Scleroderma, Systemic / etiology
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Thrombocytopenia* / complications
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Thrombocytopenia* / etiology
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Thrombocytopenia* / physiopathology
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Thrombosis* / complications
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Thrombosis* / etiology
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Thrombosis* / physiopathology