Thrombotic microangiopathies

Crit Care Clin. 2002 Apr;18(2):309-20, vi. doi: 10.1016/s0749-0704(01)00004-5.

Abstract

The thrombotic microangiopathies (TMA) are a group of diseases associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction. These seemingly disparate entities share in common a pathogenic mechanism involving endothelial injury and thrombus formation. Prognosis and treatment depend on the nature of the underlying disease.

Publication types

  • Review

MeSH terms

  • Anemia, Hemolytic* / complications
  • Anemia, Hemolytic* / etiology
  • Anemia, Hemolytic* / physiopathology
  • Endothelium, Vascular / pathology
  • Hemolytic-Uremic Syndrome / etiology
  • Humans
  • Kidney Diseases / pathology
  • Microcirculation
  • Purpura, Thrombotic Thrombocytopenic / etiology
  • Scleroderma, Systemic / etiology
  • Thrombocytopenia* / complications
  • Thrombocytopenia* / etiology
  • Thrombocytopenia* / physiopathology
  • Thrombosis* / complications
  • Thrombosis* / etiology
  • Thrombosis* / physiopathology