Drug sensitivity of Leishmania species: some unresolved problems

Trans R Soc Trop Med Hyg. 2002 Apr:96 Suppl 1:S127-9. doi: 10.1016/s0035-9203(02)90063-5.

Abstract

Leishmania species show a significant variation in their sensitivity to established and experimental drugs. Molecular techniques to identify species in clinical infections rapidly could be used to guide treatment. Molecular markers are required to detect and monitor acquired resistance to antimonial drugs. Reporter genes and the polymerase chain reaction will improve assays both in vitro and in vivo for the identification and evaluation of new drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiprotozoal Agents / pharmacology*
  • Drug Evaluation, Preclinical / methods
  • Drug Resistance
  • Humans
  • Leishmania / classification
  • Leishmania / drug effects*
  • Parasitic Sensitivity Tests

Substances

  • Antiprotozoal Agents