Effects of adsorption of acellular pertussis antigens onto different aluminium salts on the protective activity in an intranasal murine model of Bordetella pertussis infection

Vaccine. 2002 Jun 7;20(19-20):2551-5. doi: 10.1016/s0264-410x(02)00158-5.

Abstract

Adsorption of the pertussis antigens, pertussis toxoid (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) onto aluminium phosphate rather than aluminium hydroxide leads to a lower humoral response and poorer protection against intranasal pertussis challenge in mice. These effects could be reversed by inclusion of fimbriae (FIM) 2 and 3 in the formulation. These data emphasis the importance of correct formulation for such vaccines.

MeSH terms

  • Administration, Intranasal
  • Adsorption
  • Aluminum / chemistry*
  • Animals
  • Antibodies, Bacterial / biosynthesis
  • Antigens, Bacterial / chemistry*
  • Bacterial Outer Membrane Proteins / chemistry*
  • Female
  • Hemagglutinins / chemistry*
  • Mice
  • Mice, Inbred BALB C
  • Pertussis Vaccine / administration & dosage*
  • Pertussis Vaccine / immunology
  • Toxoids / chemistry*
  • Virulence Factors, Bordetella / chemistry*
  • Whooping Cough / immunology
  • Whooping Cough / prevention & control*

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Hemagglutinins
  • Pertussis Vaccine
  • Toxoids
  • Virulence Factors, Bordetella
  • pertussis toxoid
  • pertactin
  • Aluminum