[Cushing's disease in children and adolescents]

Neurochirurgie. 2002 May;48(2-3 Pt 2):271-80.
[Article in French]

Abstract

Fifty-seven unselected children and adolescents with Cushing's disease underwent transsphenoidal exploration and microadenomectomy before their 16th birthday. Hypercortisolism was corrected in 42 of the 57 patients (74%). The recurrence rate was 17% and the long-term remission rate was 57%. Diagnostic peculiarities specific surgical problems and outcome were reviewed. Direct transnasal submucosal surgery for Cushing's disease is successful, and pituitary function can be preserved in most of these young patients.

Publication types

  • Review

MeSH terms

  • ACTH Syndrome, Ectopic / complications
  • ACTH Syndrome, Ectopic / diagnosis
  • ACTH Syndrome, Ectopic / surgery
  • Adenoma / complications
  • Adenoma / epidemiology*
  • Adenoma / metabolism
  • Adenoma / surgery
  • Adolescent
  • Adrenocorticotropic Hormone / metabolism
  • Age of Onset
  • Child
  • Child, Preschool
  • Cushing Syndrome / diagnosis
  • Cushing Syndrome / epidemiology*
  • Cushing Syndrome / surgery
  • Diagnostic Imaging
  • Dwarfism, Pituitary / epidemiology
  • Dwarfism, Pituitary / etiology
  • Female
  • Follow-Up Studies
  • Humans
  • Hydrocortisone / blood
  • Hypophysectomy
  • Hypopituitarism / epidemiology
  • Hypopituitarism / etiology
  • Male
  • Microsurgery
  • Neoplasm Recurrence, Local
  • Paris / epidemiology
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / epidemiology*
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / surgery
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology
  • Remission Induction
  • Retrospective Studies
  • Risk
  • Treatment Outcome

Substances

  • Adrenocorticotropic Hormone
  • Hydrocortisone