Abstract
A couple of terfuroxan isomer pairs 1a,b and 2a,b were studied for their in vivo vasodilating activity and in vitro antiplatelet action. The haemodynamic profiles of the products resemble that of other NO-donors. Their in vitro antiaggregating activity is influenced both by terfuroxan system and by the substituents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Hemodynamics / drug effects*
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Humans
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Isomerism
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Male
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Nitric Oxide Donors / chemistry
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Nitric Oxide Donors / pharmacology
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Oxadiazoles / chemistry*
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Oxadiazoles / pharmacology*
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / chemistry*
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Platelet Aggregation Inhibitors / pharmacology*
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Swine
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Time Factors
Substances
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Nitric Oxide Donors
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Oxadiazoles
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Platelet Aggregation Inhibitors
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furoxans