A comparison of postactivation depression of synaptic actions evoked by different afferents and at different locations in the feline spinal cord

Exp Brain Res. 2002 Jul;145(1):126-9. doi: 10.1007/s00221-002-1098-5. Epub 2002 May 16.

Abstract

Postactivation depression of synaptic actions of group I and II muscle afferents and low threshold cutaneous afferents was compared with depression of actions of group Ia afferents on alpha-motoneurones in cats deeply anaesthetised with pentobarbital and alpha-chloralose. The depression was analysed on field potentials (population EPSPs). The degree of depression was evaluated by analysing changes in the monosynaptic components of the field potentials, in areas within 0.4- to 0.6-ms-long time windows from their onset. When intervals between successive stimuli used to evoke field potentials were reduced from 10 s to 0.4 s, the potentials evoked by Ia afferents in motor nuclei were depressed as described previously. Field potentials evoked by group II afferents and cutaneous afferents in the dorsal horn were similarly depressed. In contrast, monosynaptic components of field potentials evoked in the intermediate zone, by group I or II afferents, were only marginally affected. Postactivation depression of synaptic actions of group I afferents in the intermediate zone was not enhanced when test stimuli were applied 30-40 ms after a train of four conditioning stimuli. These observations indicate that the degree of postactivation depression may differ depending on the type of afferent. In addition, if postactivation depression depends on intrinsic properties of afferent terminals, differences in the degree of depression of postsynaptic potentials evoked by the same group of afferents at different locations may indicate that properties of terminals contacting different neurones may differ.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Afferent Pathways / physiology*
  • Animals
  • Cats
  • Excitatory Postsynaptic Potentials / physiology
  • Mechanoreceptors / physiology*
  • Motor Neurons / cytology
  • Motor Neurons / physiology*
  • Muscle Spindles / physiology
  • Muscle, Skeletal / innervation
  • Muscle, Skeletal / physiology
  • Neural Inhibition / physiology*
  • Skin / innervation
  • Spinal Cord / cytology
  • Spinal Cord / physiology*
  • Spinal Nerve Roots / physiology
  • Synapses / physiology*
  • Synaptic Transmission / physiology*