39 patients with oral submucous fibrosis (OSF) were divided into control and experimental groups. The control group included 22 OSF patients who were treated by oral administration of VitAD, VitBco and VitE, and the experimental group included 17 OSF patients who were treated with vitamins and tea pigment after their examinations of hemorheology. The result showed that 7 of 12 patients in the experimental group with abnormal hemorheology had average 7.9 mm improvement on the open degree (58.3%), and the open degree of other five patients (5/17) whose hemorheology was normal only increased 2 mm (20%). The therapeutic results of the experimental group (58.3%) were significantly better than that of the control group (13.6%) (P < 0.005). The results of this study indicated that tea pigment may possibly become a better therapy for the OSF patients with abnormal hemorheology.