In this multi-center study involving 412 patients, we assessed the influence of concomitant partial meniscal resection on the medium-term clinical results after anterior cruciate ligament reconstruction. We performed a resection of minimum one-third of the medial or lateral menisci in 137 patients (group M) and found intact menisci in 275 patients (group NM). Those who had undergone previous meniscal surgery, subsequent meniscal surgery or a re-rupture of the anterior cruciate ligament graft during the follow-up were not included. After a median of 3 (2-6) years, the patients were reexamined by independent observers. Group M patients had more pain, swelling and laxity than those in group NM; they also had a worse classification according to the IKDC system, lower Lysholm scores and a greater proportion of patients with loss of motion.