Abstract
Akt is a serine/threonine protein kinase that is activated by a number of growth factors and cytokines in a phosphatidylinositol-3 kinase-dependent manner. Although antiapoptotic activity of Akt is well known, it also regulates other aspects of cellular functions, including migration, glucose metabolism, and protein synthesis. In this review, Akt signaling in endothelial cells and its critical roles in the regulation of vascular homeostasis and angiogenesis will be discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Division
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Cell Movement
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Cell Survival
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Endothelium, Vascular / physiology*
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Homeostasis
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
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Models, Biological
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Neovascularization, Physiologic*
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Nitric Oxide Synthase / metabolism
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Nitric Oxide Synthase Type III
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Phosphatidylinositol 3-Kinases / metabolism
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins / physiology*
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Proto-Oncogene Proteins c-akt
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Signal Transduction
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Proto-Oncogene Proteins
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NOS3 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type III
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AKT1 protein, human
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt