[Molecular mechanisms of apoptosis. Fas and TNF systems. ICE protease system. Bcl-2 family]

L M Goga; O M Vasiliu; C R Ionescu

[Molecular mechanisms of apoptosis. Fas and TNF systems. ICE protease system. Bcl-2 family]

Rev Med Chir Soc Med Nat Iasi. 2001 Jan-Mar;105(1):23-9.

[Article in Romanian]

Authors

L M Goga¹, O M Vasiliu, C R Ionescu

Affiliation

¹ Disciplina de Biologie Celulară şi Moleculară, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

PMID: 12092154

Abstract

For every cell is a time to live and a time to die. The cell death that occurs during embryogenesis, normal tissue turnover, pathological conditions like cancer cells, etc. is "programmed cell death" or apoptosis. In this study we report on apoptosis mediated by cytokines. Fas ligand and tumor necrosis factor bind to their receptors and induce apoptosis.

Publication types

English Abstract
Review

MeSH terms

Apoptosis / physiology*
Caspases / physiology*
Fas Ligand Protein
Humans
Membrane Glycoproteins / physiology*
Mitochondria / physiology
Proto-Oncogene Proteins c-bcl-2 / physiology*
Signal Transduction
Tumor Necrosis Factor-alpha / physiology*

Substances

FASLG protein, human
Fas Ligand Protein
Membrane Glycoproteins
Proto-Oncogene Proteins c-bcl-2
Tumor Necrosis Factor-alpha
Caspases