Strained silacycles in organic synthesis: a new reagent for the enantioselective allylation of aldehydes

J Am Chem Soc. 2002 Jul 10;124(27):7920-1. doi: 10.1021/ja0264908.

Abstract

A new reagent for the enantioselective allylation of aliphatic aldehydes has been developed. The reagent is easily prepared in a single step from commercially available materials and may be stored without significant decomposition. The reactivity of the reagent is attributed to strain-release Lewis acidity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohols / chemical synthesis*
  • Aldehydes / chemistry*
  • Alkylation
  • Hydrocarbons, Cyclic / chemistry
  • Silanes / chemistry*

Substances

  • Alcohols
  • Aldehydes
  • Hydrocarbons, Cyclic
  • Silanes