From castration-induced apoptosis of prostatic epithelium to the use of apoptotic genes in the treatment of prostate cancer

Ye Zhang; Bicheng Nan; Jiang Yu; Tithi Snabboon; Francesca Andriani; Marco Marcelli

doi:10.1111/j.1749-6632.2002.tb04110.x

From castration-induced apoptosis of prostatic epithelium to the use of apoptotic genes in the treatment of prostate cancer

Ann N Y Acad Sci. 2002 Jun:963:191-203. doi: 10.1111/j.1749-6632.2002.tb04110.x.

Authors

Ye Zhang¹, Bicheng Nan, Jiang Yu, Tithi Snabboon, Francesca Andriani, Marco Marcelli

Affiliation

¹ Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine and VA Medical Center, Houston, Texas 77030, USA.

PMID: 12095944
DOI: 10.1111/j.1749-6632.2002.tb04110.x

Abstract

Current knowledge of the mechanisms regulating androgen-ablation-induced apoptosis is reviewed, and our efforts to develop a system in which genes of the apoptotic pathway are used to induce therapeutic apoptosis in experimental models of prostate cancer are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Androgens / deficiency
Androgens / physiology
Animals
Apoptosis* / genetics
Castration / adverse effects*
Epithelial Cells / pathology
Forecasting
Humans
Male
Mitochondria / physiology
Models, Animal
Prostatic Neoplasms / drug therapy
Prostatic Neoplasms / pathology*
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-bcl-2*
Rats
Receptors, Androgen / physiology
bcl-2-Associated X Protein

Substances

Androgens
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Receptors, Androgen
bcl-2-Associated X Protein