Handedness of the herpes simplex virus capsid and procapsid

Naiqian Cheng; Benes L Trus; David M Belnap; William W Newcomb; Jay C Brown; Alasdair C Steven

doi:10.1128/jvi.76.15.7855-7859.2002

Handedness of the herpes simplex virus capsid and procapsid

J Virol. 2002 Aug;76(15):7855-9. doi: 10.1128/jvi.76.15.7855-7859.2002.

Authors

Naiqian Cheng¹, Benes L Trus, David M Belnap, William W Newcomb, Jay C Brown, Alasdair C Steven

Affiliation

¹ Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

The capsid of herpes simplex virus has an icosahedral surface lattice with a nonskew triangulation number, T=16. Nevertheless, the proteins arrayed on this lattice necessarily have an intrinsic handedness. We have determined the handedness of both the herpes simplex virus type 1 capsid and its precursor procapsid by a cryoelectron microscopic tilting method.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Capsid / chemistry*
Cryoelectron Microscopy / methods
Models, Molecular
Protein Precursors / chemistry*
Simplexvirus / chemistry*
Stereoisomerism

Substances

Protein Precursors

Abstract

Publication types

MeSH terms

Substances

Grants and funding