Abstract
Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Antibodies, Viral / blood*
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Hemagglutinins, Viral / genetics
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Hemagglutinins, Viral / immunology*
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Immunization, Secondary*
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Measles / prevention & control*
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Measles Vaccine / immunology*
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Measles virus / immunology
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Mice
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Neutralization Tests
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Nicotiana / genetics
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Plants, Genetically Modified / immunology*
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Vaccines, DNA / immunology*
Substances
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Antibodies, Viral
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Hemagglutinins, Viral
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Measles Vaccine
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Vaccines, DNA
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hemagglutinin protein G, measles virus