The Authors reported the results of surgical treatment of acute gallstone cholecystitis (AGC) in patients in whom different selection criteria have been applied. Two-hundred-eighty patients with a clinical and/or ultrasonographic diagnosis of ALC were admitted to the 1st Division of General Surgery-University of Verona Italy between January 1992 and June 2001, the patients were divided into five groups according to clinical features, laboratory tests and echographic signs. A specific approach was used in the different groups. An urgent laparoscopic cholecystectomy was performed in 67 patients. Elective laparoscopic treatment after urgent US guided percutaneous cholecystostomy (US-PC) was performed in 119 and after US-PC and ERCP in 50 patients. Laparoscopic cholecystectomy was performed in 236 patients with a conversion rate of 7.6%. No mortality, 6.7% morbidity and a mean hospital stay of 7.5 days. A selective therapeutic approach to AGC allow immediate treatment in all cases and correct diagnosis of associated diseases treatment. This approach makes it possible to reduce the conversion rate of laparoscopic cholecystectomy, morbidity and mortality.