Abstract
Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.
Publication types
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Case Reports
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Autoantibodies / blood*
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Carcinoma, Small Cell / blood*
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Carcinoma, Small Cell / complications
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Carcinoma, Small Cell / pathology
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Chorea / blood*
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Chorea / complications
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Chorea / pathology
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Female
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Humans
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Lung Neoplasms / blood*
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Lung Neoplasms / complications
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Lung Neoplasms / pathology
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Male
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Middle Aged
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Nerve Tissue Proteins / blood*
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Nerve Tissue Proteins / immunology
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Paraneoplastic Syndromes, Nervous System / blood*
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Paraneoplastic Syndromes, Nervous System / complications
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Paraneoplastic Syndromes, Nervous System / pathology
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Prospective Studies
Substances
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Autoantibodies
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Nerve Tissue Proteins