Metabolic treatment of pregnancy and postdelivery period in a patient with cobalamin A disease

Am J Obstet Gynecol. 2002 Jul;187(1):225-6. doi: 10.1067/mob.2002.119637.

Abstract

We report the successful treatment of a woman with Cobalamin A disease with hydroxycobalamin injections during pregnancy and delivery and 3 months after delivery. Urine and plasma methylmalonic acid levels served to adjust therapy before and after delivery. The mother had no untoward metabolic complications and gave birth to a normal baby.

Publication types

  • Case Reports

MeSH terms

  • Cobamides / deficiency*
  • Female
  • Humans
  • Hydroxocobalamin / therapeutic use*
  • Metabolism, Inborn Errors / drug therapy*
  • Methylmalonic Acid / urine*
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Vitamin B 12 / metabolism

Substances

  • Cobamides
  • Methylmalonic Acid
  • cobamamide
  • Vitamin B 12
  • Hydroxocobalamin