The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts

Infect Immun. 2002 Aug;70(8):4701-4. doi: 10.1128/IAI.70.8.4701-4704.2002.

Abstract

Sixteen of 22 omp-1 paralogs encoding 28-kDa-range immunodominant outer membrane proteins of Ehrlichia chaffeensis were transcribed in blood monocytes of dogs throughout a 56-day infection period. Only one paralog was transcribed by E. chaffeensis in three developmental stages of Amblyomma americanum ticks before or after E. chaffeensis transmission to naïve dogs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacterial Outer Membrane Proteins / genetics*
  • Disease Models, Animal
  • Dogs
  • Ehrlichia chaffeensis / genetics*
  • Ehrlichiosis / microbiology*
  • Gene Expression*
  • Genes, Bacterial*
  • Male
  • Multigene Family*
  • RNA, Ribosomal, 16S
  • Ticks / microbiology

Substances

  • Bacterial Outer Membrane Proteins
  • RNA, Ribosomal, 16S