Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment

Margaret E McLaughlin; Tyler Jacks

doi:10.1016/s1535-6108(02)00078-8

Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment

Cancer Cell. 2002 Jun;1(5):408-10. doi: 10.1016/s1535-6108(02)00078-8.

Authors

Margaret E McLaughlin¹, Tyler Jacks

Affiliation

¹ Howard Hughes Medical Institute, Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.

PMID: 12124168
DOI: 10.1016/s1535-6108(02)00078-8

Abstract

Deletion of both copies of the Nf1 gene in Schwann cells combined with Nf1 heterozygosity in the tumor environment promotes neurofibroma formation in mice.

Publication types

Review

MeSH terms

Animals
Cell Transformation, Neoplastic
Gene Deletion*
Genes, Neurofibromatosis 1 / physiology*
Humans
Loss of Heterozygosity*
Mice
Mice, Transgenic
Neurofibroma / genetics*
Schwann Cells / metabolism