We have chosen to provide a brief review of only three of the numerous existing, emerging or future applications of novel technologies that provide noninvasive testing. Clinical laboratory testing over the recent decades has been characterized by a remarkable increase in the variety and volume of [figure: see text] information made available to assist physicians in the practice of medicine. Among current trends that facilitate prompt delivery of results, noninvasive testing holds great promise. Technologies that already exist or that have not yet been developed may extend the opportunities to exploit this approach. Noninvasive testing has other obvious attractive features; safety, painlessness and adaptability to special care situations. Our profession may well enjoy additional vitalization from the further evolution of this facinating and important field.