Abstract
Vancomycin and rifampicin replaced cephazolin as antibiotic prophylaxis for coronary artery bypass surgery at our institution. Following this intervention, there was a significant decrease (P < .001) in the surgical-site infection rate from 10.5 (95% confidence interval, 8.2 to 13.3) to 4.9 (95% confidence interval, 3.2 to 7.1) infections per 100 procedures. An estimated $576,655 (Australian) was saved between two 12-month periods.
MeSH terms
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Administration, Oral
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Anti-Bacterial Agents / administration & dosage
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Antibiotic Prophylaxis*
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Coronary Artery Bypass / adverse effects*
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Coronary Artery Bypass / economics
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Cost-Benefit Analysis
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Drug Therapy, Combination / administration & dosage*
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Female
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Humans
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Injections, Intravenous
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Male
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Middle Aged
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Rifampin / administration & dosage*
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Surgical Wound Infection / economics
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Surgical Wound Infection / prevention & control*
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Vancomycin / administration & dosage*
Substances
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Anti-Bacterial Agents
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Vancomycin
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Rifampin