Epsilon-aminocaproic acid and renal complications: case report and review of the literature

Clin Nephrol. 2002 Jul;58(1):63-7. doi: 10.5414/cnp58063.

Abstract

Epsilon-aminocaproic acid (EACA) is a potent anti-fibrinolytic agent that is used in the treatment of excessive bleeding resulting from a systemic fibrinolytic state. It can also be used to treat hematuria through its action on decreasing urinary fibrinolysis. A broad range of renal complications has been ascribed to EACA. Although they are rare, they may be life-threatening and should therefore be immediately recognized.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Aged
  • Aminocaproic Acid / adverse effects*
  • Aminocaproic Acid / therapeutic use
  • Antifibrinolytic Agents / adverse effects*
  • Antifibrinolytic Agents / therapeutic use
  • Creatinine / blood
  • Female
  • Hematuria
  • Humans
  • Hydronephrosis / diagnostic imaging
  • Hydronephrosis / etiology
  • Kidney / diagnostic imaging
  • Nephrostomy, Percutaneous
  • Radiography
  • Thrombosis / drug therapy
  • Ultrasonography

Substances

  • Antifibrinolytic Agents
  • Creatinine
  • Aminocaproic Acid