The effect of fluoride and hypothermia on the in vitro metabolism of mivacurium

Anesth Analg. 2002 Aug;95(2):397-9, table of contents. doi: 10.1097/00000539-200208000-00029.

Abstract

The fluoride inhibition of mivacurium hydrolysis by pseudocholinesterase increases in hypothermia, but it will very rarely occur in clinical practice because it requires rather large fluoride concentrations (>50 micromol/L) and very low temperatures (<28 degrees C).

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Butyrylcholinesterase / blood
  • Butyrylcholinesterase / metabolism
  • Cholinesterase Inhibitors / pharmacology
  • Female
  • Fluorides / pharmacology*
  • Half-Life
  • Humans
  • Hypothermia, Induced*
  • Isoquinolines / chemistry
  • Isoquinolines / metabolism*
  • Male
  • Mivacurium
  • Neuromuscular Nondepolarizing Agents / chemistry
  • Neuromuscular Nondepolarizing Agents / metabolism*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Cholinesterase Inhibitors
  • Isoquinolines
  • Neuromuscular Nondepolarizing Agents
  • Mivacurium
  • Butyrylcholinesterase
  • Fluorides