Non-steroidal pregnancy-terminating agents: design, synthesis and structure-activity relationships of 2-aryl-1,2,4-triazolo[1,5-a]pyridine

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2411-3. doi: 10.1016/s0960-894x(02)00399-2.

Abstract

The syntheses and the pregnancy-terminating activity relationships of compounds -n are reported. Compounds 5b and are found to be more potent than DL-111-a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortifacient Agents, Nonsteroidal / chemical synthesis*
  • Abortifacient Agents, Nonsteroidal / pharmacology
  • Animals
  • Drug Design
  • Embryo Implantation / drug effects
  • Embryo, Mammalian / drug effects
  • Luteolysis / drug effects
  • Luteolytic Agents / chemical synthesis
  • Luteolytic Agents / pharmacology
  • Mice
  • Pyridines / chemical synthesis
  • Pyridines / pharmacology
  • Structure-Activity Relationship
  • Triazoles / chemical synthesis
  • Triazoles / pharmacology

Substances

  • Abortifacient Agents, Nonsteroidal
  • Luteolytic Agents
  • Pyridines
  • Triazoles
  • 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole