Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection

J Virol. 2002 Sep;76(17):8963-5. doi: 10.1128/jvi.76.17.8963-8965.2002.

Abstract

Antiviral therapy induces a rapid drop in human immunodeficiency virus type 1 viremia, but the decline of virus levels decelerates over time. Mathematical modeling demonstrates that the source of residual virus production might be a single compartment of latently infected cells with an extended distribution of activation rates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiretroviral Therapy, Highly Active*
  • CD4-Positive T-Lymphocytes / virology*
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV-1 / physiology*
  • Humans
  • Models, Biological
  • Time Factors
  • Virus Activation
  • Virus Latency*
  • Virus Replication