Community-based research has emerged as a vital strategy for developing effective, culturally relevant health interventions. This article describes the strengths and challenges of building a collaborative research partnership based on equality between academic researchers, public health practitioners, and representatives from community-based organizations. The model of collaboration adopted for the Fathers and Sons Project is described and examples of model applications are discussed. Lessons learned in the form of strengths/benefits and potential pitfalls in developing a community-based intervention designed to enhance the health behaviors of African American nonresidential fathers and their sons are provided.