Abstract
Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D(1) receptor and D(2) receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Autoradiography
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Carrier Proteins / analysis
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Carrier Proteins / metabolism*
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Corpus Striatum / chemistry
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Corpus Striatum / metabolism
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Corpus Striatum / pathology
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Dopamine / analysis
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Dopamine / metabolism*
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Dopamine Plasma Membrane Transport Proteins
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Dystonia Musculorum Deformans / metabolism*
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Dystonia Musculorum Deformans / pathology
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Humans
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Membrane Glycoproteins / analysis
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Membrane Glycoproteins / metabolism
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Membrane Transport Proteins / analysis
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Membrane Transport Proteins / metabolism
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Middle Aged
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Molecular Chaperones*
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Nerve Tissue Proteins*
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Neuropeptides*
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Receptors, Dopamine / analysis
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Receptors, Dopamine / metabolism
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Vesicular Biogenic Amine Transport Proteins
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Vesicular Monoamine Transport Proteins
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Molecular Chaperones
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Nerve Tissue Proteins
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Neuropeptides
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Receptors, Dopamine
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TOR1A protein, human
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Vesicular Biogenic Amine Transport Proteins
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Vesicular Monoamine Transport Proteins
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Dopamine