Beckmann rearrangement of oximes under very mild conditions

J Org Chem. 2002 Aug 23;67(17):6272-4. doi: 10.1021/jo025960d.

Abstract

A variety of ketoximes, easily prepared from the corresponding ketones, undergo the Beckmann rearrangement upon treatment with 2,4,6-trichloro[1,3,5]triazine in N,N-dimethylformamide at room temperature in excellent yields. This procedure can be applied to aldoximes for obtaining the corresponding nitriles.