Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides

Norbert Wimmer; Robert J Marano; Philip S Kearns; Elizabeth P Rakoczy; Istvan Toth

doi:10.1016/s0960-894x(02)00511-5

Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2635-7. doi: 10.1016/s0960-894x(02)00511-5.

Authors

Norbert Wimmer¹, Robert J Marano, Philip S Kearns, Elizabeth P Rakoczy, Istvan Toth

Affiliation

¹ School of Pharmacy, The University of Queensland, Steele Building, St. Lucia, Qld 4072, Australia.

PMID: 12182876
DOI: 10.1016/s0960-894x(02)00511-5

Abstract

Synthesis of novel polycationic lipophilic peptide core(s) was accomplished and these agents successfully transfected human retinal pigment epithelium cells with ODN1 upon complexation with the oligonucleotide. The level of transfection was indirectly measured by the decreased production of the protein hVEGF (human vascular endothelial growth factor) in comparison to the transfection agent cytofectin GSV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Endothelial Growth Factors / genetics
Humans
Intercellular Signaling Peptides and Proteins / genetics
Lymphokines / genetics
Oligonucleotides / chemistry*
Oligonucleotides / genetics
Peptides / chemistry*
Polyamines / chemical synthesis*
Polyamines / chemistry
Polyelectrolytes
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors

Substances

Endothelial Growth Factors
Intercellular Signaling Peptides and Proteins
Lymphokines
Oligonucleotides
Peptides
Polyamines
Polyelectrolytes
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
polycations