Abstract
A 55-year-old man suffered a cutaneous relapse of an LMP1-positive follicular lymphoma after treatment with antithymocyte globulin and cyclosporine A (CSA) for a hepatitis-associated aplastic anaemia (AA). Rituximab was not effective, so CSA was tapered off. Lymphoma masses did not regress but AA relapsed. A second remission of both lymphoma and AA was achieved with high-dose cyclophosphamide, but the patient died of a bilateral pneumonia. The relationships between immunosuppression, viral reactivation and tumour growth are discussed. The use of rituximab and lamivudine in immunodepressed patients is also commented.
Copyright 2002 S. Karger AG, Basel
MeSH terms
-
Anemia, Aplastic / drug therapy*
-
Anemia, Aplastic / etiology
-
Anemia, Aplastic / virology
-
Antilymphocyte Serum / administration & dosage
-
Antilymphocyte Serum / adverse effects
-
Cyclosporine / administration & dosage
-
Cyclosporine / adverse effects
-
Fatal Outcome
-
Hepatitis, Viral, Human / complications
-
Hepatitis, Viral, Human / virology
-
Herpesvirus 4, Human / growth & development
-
Humans
-
Iatrogenic Disease*
-
Immunosuppression Therapy / adverse effects*
-
Immunosuppression Therapy / methods
-
Lymphoma, Follicular / chemistry*
-
Lymphoma, Follicular / pathology*
-
Lymphoma, Follicular / virology
-
Male
-
Middle Aged
-
Recurrence
-
Skin Neoplasms / chemistry
-
Skin Neoplasms / pathology
-
Skin Neoplasms / virology
-
Viral Matrix Proteins* / analysis
-
Virus Activation / drug effects
Substances
-
Antilymphocyte Serum
-
EBV-associated membrane antigen, Epstein-Barr virus
-
Viral Matrix Proteins
-
Cyclosporine