Benign mesenchymal tumors of the bladder are rare. Leiomyoma is the most common mesenchymal tumor of the bladder. We report a new case. A 50-year-old woman presented with total hematuria. Complementary investigations (ultrasonographic, intravenous urography) showed an intravesical solid mass, arising from the bladder dome. Cystoscopic examination suggested a benign tumor, which was confirmed by pathologic assessment of biopsy. Partial cystectomy was performed. Postoperative course was uneventful. Pathologic examination showed a leiomyoma. Leiomyoma of the urinary bladder is a rare benign tumor. Its prognosis is good, the treatment being exclusively surgical.