Abstract
Among the different methods used to increase the aqueous drug solubility, the preparation of a solid dispersion with a soluble carrier represents an interesting formulative approach. We substituted polyvinylalcohol with triethyleneglycolmonoethylether and obtained a suitable material for the formulation of a solid dispersion of progesterone, by spray-drying. In particular, we evaluated the influence of the polyvinylalcohol substitution degree and the polymer-drug weight ratios in the preparative mixture on the progesterone dissolution rate in the aqueous environment.
MeSH terms
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Calorimetry, Differential Scanning
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry*
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Drug Compounding
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Drug Incompatibility
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Gonadal Steroid Hormones / chemistry
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Hydrophobic and Hydrophilic Interactions
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Pharmaceutic Aids / chemical synthesis
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Pharmaceutic Aids / chemistry*
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Polyethylene Glycols / chemical synthesis
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Polyethylene Glycols / chemistry*
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Polymers
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Polyvinyl Alcohol / chemical synthesis
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Polyvinyl Alcohol / chemistry*
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Progesterone / chemistry
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Solubility
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Time Factors
Substances
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Drug Carriers
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Gonadal Steroid Hormones
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Pharmaceutic Aids
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Polymers
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Polyethylene Glycols
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triethylene glycol monoethyl ether
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Progesterone
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Polyvinyl Alcohol