Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome

Neurology. 2002 Aug 27;59(4):639-41. doi: 10.1212/wnl.59.4.639.

Abstract

Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Aged
  • Carrier Proteins / cerebrospinal fluid*
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Middle Aged
  • Neuropeptides / cerebrospinal fluid*
  • Orexins
  • Polysomnography
  • Reference Values
  • Restless Legs Syndrome / cerebrospinal fluid*
  • Restless Legs Syndrome / diagnosis
  • Severity of Illness Index
  • Time Factors

Substances

  • Carrier Proteins
  • HCRT protein, human
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins