Abstract
Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.
Publication types
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Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age of Onset
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Aged
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Carrier Proteins / cerebrospinal fluid*
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Female
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Humans
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Intracellular Signaling Peptides and Proteins*
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Male
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Middle Aged
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Neuropeptides / cerebrospinal fluid*
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Orexins
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Polysomnography
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Reference Values
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Restless Legs Syndrome / cerebrospinal fluid*
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Restless Legs Syndrome / diagnosis
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Severity of Illness Index
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Time Factors
Substances
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Carrier Proteins
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HCRT protein, human
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexins