Abstract
New 3-(2,3-dimethyl-1-phenyl-4-pyrazolon-5-yl)-4-thiazolidones were synthesized. The structure of substances was supported by UV- and 1H-NMR spectra. Some compounds were tested in vivo for their antiinflammatory activity. Were confirmed previous results about structure-activity relationships.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Edema / chemically induced
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Edema / prevention & control
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Female
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Male
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Rats
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Spectrophotometry, Ultraviolet
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Indicators and Reagents
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Thiazoles