In vitro glucocorticoid resistance in childhood leukemia correlates with receptor affinity determined at 37 degrees C, but not with affinity determined at room temperature

Leukemia. 2002 Sep;16(9):1882-4. doi: 10.1038/sj.leu.2402606.
No abstract available

Publication types

  • Letter

MeSH terms

  • Acute Disease
  • Antineoplastic Agents, Hormonal / metabolism*
  • Bone Marrow / chemistry
  • Child
  • Dexamethasone / metabolism*
  • Drug Resistance, Neoplasm
  • Humans
  • In Vitro Techniques
  • Leukemia, Myeloid / blood
  • Leukemia, Myeloid / drug therapy
  • Leukemia, Myeloid / metabolism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Receptors, Glucocorticoid / metabolism*
  • Temperature

Substances

  • Antineoplastic Agents, Hormonal
  • Receptors, Glucocorticoid
  • Dexamethasone